Molecular basis of Streptococcus mutans sortase A inhibition by the flavonoid natural product trans-chalcone
نویسندگان
چکیده
منابع مشابه
Molecular basis of Streptococcus mutans sortase A inhibition by the flavonoid natural product trans-chalcone.
Sortase A (SrtA) from Gram positive pathogens is an attractive target for inhibitors due to its role in the attachment of surface proteins to the cell wall. We found that the plant natural product trans-chalcone inhibits Streptococcus mutans SrtA in vitro and also inhibited S. mutans biofilm formation. Mass spectrometry revealed that the trans-chalcone forms a Michael addition adduct with the a...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2015
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c5cc01816a